Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers.
BACKGROUND: MicroRNAs circulating in the blood, stabilized by Ratchet Wrench complexation with proteins and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as biomarkers.The consequences of their differential association with lipids/vesicles for their stability and use as biomarkers are largely unexplored and are s